Efficacy of Glimepiride in Patients with Poorly Controlled Insulin-treated Type 2 Diabetes Mellitus

We retrospectively investigated the effects of adding glimepiride in patients with type 2 diabetes showing suboptimal control by insulin therapy. Of 63 patients with poorly controlled insulin-treated type 2 diabetes (baseline HbA1c, 8.4 ± 0.6%), 32 were treated with insulin alone and 31 were given g...

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Veröffentlicht in:	Endocrine Journal 2005, Vol.52(5), pp.563-569
Hauptverfasser:	OSE, Hiroyuki, FUKUI, Michiaki, KITAGAWA, Yoshihiro, HIRATA, Chizuko, ICHIO, Naoko, KADONO, Mayuko, MOGAMI, Shin-ichi, ONISHI, Masayoshi, ICHIDA, Yukiko, NAKAJIMA, Toshiki, HASEGAWA, Goji, YOSHIKAWA, Toshikazu, NAKAMURA, Naoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood Glucose - metabolism C-Peptide - blood Diabetes Mellitus, Type 2 - drug therapy Drug Therapy, Combination Female Glimepiride Glycated Hemoglobin A - analysis Humans Insulin Insulin - administration & dosage Insulin - therapeutic use Male Middle Aged Retrospective Studies Sulfonylurea Compounds - therapeutic use Type 2 diabetes
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Zusammenfassung:	We retrospectively investigated the effects of adding glimepiride in patients with type 2 diabetes showing suboptimal control by insulin therapy. Of 63 patients with poorly controlled insulin-treated type 2 diabetes (baseline HbA1c, 8.4 ± 0.6%), 32 were treated with insulin alone and 31 were given glimepiride in addition to insulin. HbA1c values, daily insulin dose, body weight, blood pressure, plasma lipid concentrations, and the number of hypoglycemic events were recorded at weeks 0, 12, 24, 36, 48, 60, and 72. HbA1c decreased by 1.1%, from 8.5 ± 0.6% to 7.4 ± 0.8% (P
ISSN:	0918-8959 1348-4540
DOI:	10.1507/endocrj.52.563