Nanocompatible Chemistry toward Fabrication of Target-Specific Gold Nanoparticles

Nanocompatible Chemistry toward Fabrication of Target-Specific Gold Nanoparticles

Nanocompatible chemistry which utilizes a novel nontoxic phosphino amino acid as a reducing agent has resulted in the development of therapeutically useful gold nanoparticles under biologically benign media. Stabilization of gold nanoparticles by the edible gum arabic matrix has provided an effectiv...

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Veröffentlicht in:Journal of the American Chemical Society 2006-09, Vol.128 (35), p.11342-11343
Hauptverfasser: Kannan, Raghuraman, Rahing, Valerie, Cutler, Cathy, Pandrapragada, Ravi, Katti, Kavita K, Kattumuri, Vijaya, Robertson, J. David, Casteel, Stan J, Jurisson, Silvia, Smith, Charles, Boote, Evan, Katti, Kattesh V
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacokinetics
Chemistry
Drug Stability
Exact sciences and technology
General and physical chemistry
Gold - chemistry
Gold - pharmacokinetics
Metal Nanoparticles - chemistry
Mice
Mice, Inbred Strains
Microscopy, Electron, Transmission
Nanomedicine
Particle Size
Surface Properties
Tissue Distribution
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Zusammenfassung:Nanocompatible chemistry which utilizes a novel nontoxic phosphino amino acid as a reducing agent has resulted in the development of therapeutically useful gold nanoparticles under biologically benign media. Stabilization of gold nanoparticles by the edible gum arabic matrix has provided an effective pathway toward in vivo stable target-specific gold nanoparticles.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja063280c