Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells

Patterns of protein expression can be used to identify biomarkers of disease, prognosis or treatment response. Peripheral 5-HT2A and D3 receptors have been proposed as protein markers in schizophrenia. We investigated the possible parallel regulation of these candidate biomarkers in central nervous...

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Veröffentlicht in:	Neuropharmacology 2006-09, Vol.51 (4), p.923-932
Hauptverfasser:	Padín, J Fernando, Rodríguez, Miguel A, Domínguez, Eduardo, Dopeso-Reyes, Iria G, Buceta, Montserrat, Cano, Ernesto, Sotelo, Eddy, Brea, José, Caruncho, Hector J, Isabel Cadavid, M, Castro, Marián, Isabel Loza, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzodiazepines - pharmacology Blood Cells - drug effects Blotting, Northern - methods Central Nervous System - drug effects Central Nervous System - metabolism Dopamine Antagonists - pharmacokinetics Gene Expression Regulation - drug effects Haloperidol - pharmacokinetics Ketanserin - pharmacokinetics Lymphocytes - drug effects Lymphocytes - metabolism Male Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2A - genetics Receptor, Serotonin, 5-HT2A - metabolism Receptors, Dopamine D3 - genetics Receptors, Dopamine D3 - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Serotonin Antagonists - pharmacokinetics Serotonin Uptake Inhibitors - pharmacology Tritium - pharmacokinetics
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Zusammenfassung:	Patterns of protein expression can be used to identify biomarkers of disease, prognosis or treatment response. Peripheral 5-HT2A and D3 receptors have been proposed as protein markers in schizophrenia. We investigated the possible parallel regulation of these candidate biomarkers in central nervous system (CNS) and peripheral blood cells by a comparative study of the effects of antipsychotic treatment on the expression of the receptors in both systems in rats. Acute (24 and 48 h) and subchronic (16 days) treatment of rats with olanzapine induced a significant decrease in 5-HT2A receptor density both in frontal cortex (Bmax=76.2%, 83.0% and 46.0% of control after 24 h, 48 h and 16 days of treatment, respectively; P
ISSN:	0028-3908
DOI:	10.1016/j.neuropharm.2006.06.005