Prevention of Adhesion and Promotion of Pseudoislets Formation from a β-Cell Line by Fluorocarbon Emulsions

So far, but no further. A perfluorocarbon (PFC) emulsion induces formation of pseudoislets from MIN6 b‐cells that, in the absence of PFC, form a monolayer. MIN6 pseudoislets secrete insulin under glucose stimulation and have potential in the therapy of type‐1 diabetes. In addition, PFC emulsions are...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2006-08, Vol.7 (8), p.1160-1163
Hauptverfasser:	Sanchez Dominguez, Margarita, Maillard, Elisa, Krafft, Marie Pierre, Sigrist, Séverine, Belcourt, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cell adhesion Cell Adhesion - drug effects Cell Line emulsions Emulsions - chemistry Emulsions - pharmacology fluorocarbons Fluorocarbons - chemistry Fluorocarbons - pharmacology Islets of Langerhans - cytology Islets of Langerhans - drug effects Mice pancreatic islets pseudoislets type 1 diabetes
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Beschreibung
Zusammenfassung:	So far, but no further. A perfluorocarbon (PFC) emulsion induces formation of pseudoislets from MIN6 b‐cells that, in the absence of PFC, form a monolayer. MIN6 pseudoislets secrete insulin under glucose stimulation and have potential in the therapy of type‐1 diabetes. In addition, PFC emulsions are expected to facilitate islet graft survival, owing to their oxygen‐carrying capacity.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.200600056