A Case of Weber-Christian Disease With Collapsing Glomerulopathy
We report a case of Weber-Christian disease confirmed by skin biopsy in a patient who presented with collapsing glomerulopathy and lipophagic interstitial nephritis. On renal biopsy, glomerular visceral epithelial cells, tubular cells, and interstitial macrophages were loaded with inclusions that we...
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Veröffentlicht in: | American journal of kidney diseases 2006-09, Vol.48 (3), p.484-488 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | We report a case of Weber-Christian disease confirmed by skin biopsy in a patient who presented with collapsing glomerulopathy and lipophagic interstitial nephritis. On renal biopsy, glomerular visceral epithelial cells, tubular cells, and interstitial macrophages were loaded with inclusions that were morphologically consistent with oxidized lipoproteins, suggesting that lipids derived from the panniculitis may have an etiopathogenic role. |
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ISSN: | 0272-6386 1523-6838 |
DOI: | 10.1053/j.ajkd.2006.05.025 |