Regulatory role of Na,K-ATPase in the growth of heart tissue explants in organotypic culture

We studied the effects of ouabain, norepinephrine, and acetylcholine on the growth of heart tissue explants from 10-12-old chicken embryos in an organotypic culture. Ouabain, norepinephrine, and acetylcholine stimulated the growth of explants. Our results suggest that trophic function of acetylcholi...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-08, Vol.140 (2), p.184-186
Hauptverfasser:	Lopatina, E V, Penniyainen, V A, Zaika, A A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Cells, Cultured Chick Embryo Dose-Response Relationship, Drug Gene Expression Regulation Heart - anatomy & histology Myocardium - metabolism Norepinephrine - pharmacology Organ Culture Techniques - methods Ouabain - pharmacology Signal Transduction Sodium-Potassium-Exchanging ATPase - chemistry Sodium-Potassium-Exchanging ATPase - physiology
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Beschreibung
Zusammenfassung:	We studied the effects of ouabain, norepinephrine, and acetylcholine on the growth of heart tissue explants from 10-12-old chicken embryos in an organotypic culture. Ouabain, norepinephrine, and acetylcholine stimulated the growth of explants. Our results suggest that trophic function of acetylcholine and norepinephrine is associated with regulation of Na,K-ATPase activity as a signal transducer.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0440-x