Oral misoprostol for induction of labor in prelabor rupture of membranes (PROM) at term: a randomized control trial

Objective. To compare the efficacy of two different dosages of oral misoprostol (50 and 100 µg) with control, in medical induction of labor for patients with prelabor rupture of membranes (PROM) at term. Methods. One hundred women with PROM at term were randomized to receive placebo (vitamin B6 50 mg, control), 50 µg (treatment group 1), or 100 µg (treatment group 2) of oral misoprostol every 4 h to a maximum of six doses. The main outcome measures included time interval from onset of PROM to delivery, duration of first stage of labor, and occurrence of vaginal delivery within 24 h from PROM. Results. The time intervals from PROM to delivery were significantly reduced in both treatment groups compared to control (control, 25.1±10.5 h; treatment group 1, 14.5±6.2 h; and treatment group 2, 13.0±6.1 h, p