Rx-Cre, a tool for inactivation of gene expression in the developing retina

Rx is a homeobox‐containing gene that is critical for vertebrate eye development. Its expression domain delineates a field of cells from which the retina and the ventral hypothalamus develop. The 5′ upstream regulatory sequences of the medaka fish Rx gene are functionally conserved during evolution...

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Veröffentlicht in:Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2006-08, Vol.44 (8), p.361-363
Hauptverfasser: Swindell, Eric C., Bailey, Travis J., Loosli, Felix, Liu, Chaomei, Amaya-Manzanares, Felipe, Mahon, Kathleen A., Wittbrodt, Joachim, Jamrich, Milan
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Sprache:eng
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Zusammenfassung:Rx is a homeobox‐containing gene that is critical for vertebrate eye development. Its expression domain delineates a field of cells from which the retina and the ventral hypothalamus develop. The 5′ upstream regulatory sequences of the medaka fish Rx gene are functionally conserved during evolution to a degree that they direct gene expression into the Rx‐expressing field of cells in mice. Using these sequences, we made a Cre line that can be used for inactivation of gene expression in the developing retina. genesis 44:361–363, 2006. Published 2006 Wiley‐Liss, Inc.
ISSN:1526-954X
1526-968X
DOI:10.1002/dvg.20225