ZOning out Tight Junctions

The tight junction is an intricate seal between adjoining epithelial cells that also separates the apical and basolateral membranes within these cells. A paper in this issue of Cell by Umeda et al. (2006) demonstrates that loss of the ZO scaffolding proteins prevents the formation of tight junctions...

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Veröffentlicht in:	Cell 2006-08, Vol.126 (4), p.647-649
Hauptverfasser:	Shin, Kunyoo, Margolis, Ben
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Polarity Epithelial Cells - cytology Epithelial Cells - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Phosphoproteins - genetics Phosphoproteins - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Tight Junctions - chemistry Tight Junctions - metabolism Zonula Occludens-1 Protein
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Beschreibung
Zusammenfassung:	The tight junction is an intricate seal between adjoining epithelial cells that also separates the apical and basolateral membranes within these cells. A paper in this issue of Cell by Umeda et al. (2006) demonstrates that loss of the ZO scaffolding proteins prevents the formation of tight junctions but surprisingly does not perturb apico-basal polarity.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2006.08.005