Bisoxazolidine-Catalyzed Enantioselective Alkynylation of Aldehydes

A C2-symmetric bisoxazolidine derived from aminoindanol has been successfully applied in the asymmetric alkynylation of aldehydes. The ligand is readily available, has a wide substrate scope, and catalyzes the formation of chiral propargylic alcohols with excellent yields and enantioselectivties.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2006-08, Vol.128 (34), p.10996-10997
Hauptverfasser:	Wolf, Christian, Liu, Shuanglong
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology General and physical chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A C2-symmetric bisoxazolidine derived from aminoindanol has been successfully applied in the asymmetric alkynylation of aldehydes. The ligand is readily available, has a wide substrate scope, and catalyzes the formation of chiral propargylic alcohols with excellent yields and enantioselectivties.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja062711o