Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease

LRRK2 G2019S is the most common known cause of Parkinson disease (PD) in patients of European origin, but little is known about its distribution in other populations. The authors identified two of 586 Japanese patients with PD heterozygous for the mutation who shared a haplotype distinct from that o...

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Veröffentlicht in:	Neurology 2006-08, Vol.67 (4), p.697-699
Hauptverfasser:	ZABETIAN, C. P, MORINO, H, ROBERTS, J. W, YEAROUT, D, SAMII, A, KAWAKAMI, H, UJIKE, H, YAMAMOTO, M, ODA, M, MARUYAMA, H, IZUMI, Y, KAJI, R, GRIFFITH, A, LEIS, B. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Mutational Analysis Female Genetic Markers - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Haplotypes - genetics Humans Japan - epidemiology Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Mutation Neurology Parkinson Disease - epidemiology Parkinson Disease - genetics Prevalence Protein-Serine-Threonine Kinases - genetics Risk Assessment - methods Risk Factors Washington - epidemiology
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Zusammenfassung:	LRRK2 G2019S is the most common known cause of Parkinson disease (PD) in patients of European origin, but little is known about its distribution in other populations. The authors identified two of 586 Japanese patients with PD heterozygous for the mutation who shared a haplotype distinct from that observed in Europeans. This suggests that G2019S originated from separate founders in Europe and Japan and is more widely dispersed than previously recognized.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.wnl.0000227732.37801.d4