Encapsulation of Single Enzyme in Nanogel with Enhanced Biocatalytic Activity and Stability

Single protein encapsulated into nanogels with uniformed size and controllable shell thickness were prepared by surface acryloylation of a protein molecule followed by aqueous in situ polymerization. Compared to its free counterpart, the encapsulated protein exhibits similar biocatalytic behavior an...

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Veröffentlicht in:	Journal of the American Chemical Society 2006-08, Vol.128 (34), p.11008-11009
Hauptverfasser:	Yan, Ming, Ge, Jun, Liu, Zheng, Ouyang, Pingkai
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Chemistry Enzyme Stability Exact sciences and technology Gels General and physical chemistry Horseradish Peroxidase - metabolism Microscopy, Electron, Transmission Nanostructures
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Beschreibung
Zusammenfassung:	Single protein encapsulated into nanogels with uniformed size and controllable shell thickness were prepared by surface acryloylation of a protein molecule followed by aqueous in situ polymerization. Compared to its free counterpart, the encapsulated protein exhibits similar biocatalytic behavior and significantly improved stability at high temperature and in the presence of organic solvent.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja064126t