Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis

Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis

Chymase, a serine protease, is stored mainly in secretory granules of human mast cells. Serum chymase concentration was examined in 8 autopsy cases with anaphylaxis as well as in 104 control cases without anaphylaxis. It was detected in all 8 cases with anaphylaxis (range 3-380 ng/ml, mean 89.8 ng/m...

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Veröffentlicht in:International journal of legal medicine 2005-11, Vol.119 (6), p.331-334
Hauptverfasser: Nishio, Hajime, Takai, Shinji, Miyazaki, Mizuo, Horiuchi, Hidekazu, Osawa, Motoki, Uemura, Koichi, Yoshida, Ken-ichi, Mukaida, Masahiro, Ueno, Yasuhiro, Suzuki, Koichi
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Anaphylaxis
Anaphylaxis - blood
Anaphylaxis - diagnosis
Antibiotics
Autopsies
Case-Control Studies
Child, Preschool
Chymases
Female
Forensic medicine
Forensic Pathology
Heart attacks
Humans
Legal medicine
Male
Medical schools
Middle Aged
Postmortem Changes
Serine Endopeptidases - blood
Tryptases
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Zusammenfassung:Chymase, a serine protease, is stored mainly in secretory granules of human mast cells. Serum chymase concentration was examined in 8 autopsy cases with anaphylaxis as well as in 104 control cases without anaphylaxis. It was detected in all 8 cases with anaphylaxis (range 3-380 ng/ml, mean 89.8 ng/ml), while it was detected in only 2 of the 104 controls and was below a detectable level (
ISSN:0937-9827
1437-1596
DOI:10.1007/s00414-005-0524-1