Mass Spectrometric Profiling of Intact Biological Tissue by Using Desorption Electrospray Ionization

Mass Spectrometric Profiling of Intact Biological Tissue by Using Desorption Electrospray Ionization

Direct chemical profiling of biological tissues, including metastatic human‐liver adenocarcinoma, was carried out by using mass spectrometry under ambient conditions. Desorption electrospray ionization revealed enhanced signals from sphingolipids and increased unsaturation levels of the phospholipid...

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Veröffentlicht in:Angewandte Chemie International Edition 2005-11, Vol.44 (43), p.7094-7097
Hauptverfasser: Wiseman, Justin M., Puolitaival, Satu M., Takáts, Zoltán, Cooks, R. Graham, Caprioli, Richard M.
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - chemistry
Adipose Tissue - chemistry
Animals
Brain
Humans
imaging agents
ionization
Lipids - chemistry
Liver - chemistry
Liver - pathology
Liver Neoplasms - chemistry
mass spectrometry
Mice
Pancreas - chemistry
phospholipids
Rats
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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Zusammenfassung:Direct chemical profiling of biological tissues, including metastatic human‐liver adenocarcinoma, was carried out by using mass spectrometry under ambient conditions. Desorption electrospray ionization revealed enhanced signals from sphingolipids and increased unsaturation levels of the phospholipids in the tumor region of the tissue (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502362