New Bis-spirolabdane-Type Diterpenoids from Leonurus heterophyllus SW

Twelve natural bis-spirolabdane-type diterpenoids, including eight new, named leoheteronones A—E (3, 6, 8, 9, 11), 15-epileoheteronones B (7), D (10), and E (12), and four known leopersin B (1), 15-epileopersin B (2), leopersin C (4), and 15-epileopersin C (5), together with hispanone (13) and galeopsin (14) were isolated from the aerial parts of the medicinal plant Leonurus heterophyllus SW. (Lamiaceae) grown in Vietnam. Their structures were determined by spectroscopic analyses. The current study emphasized the accumulation of C-15 oxygenated bis-spirolabdane-type diterpenoids of both 13R and 13S configurations in L. heterophyllus.