NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

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Veröffentlicht in:	Nature medicine 2005-11, Vol.11 (11), p.1135-1136
Hauptverfasser:	Krajewski, Marcin, Ozdowy, Przemyslaw, D'Silva, Loyola, Rothweiler, Ulli, Holak, Tad A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Biomedical and Life Sciences Biomedicine Cancer Research Chromatography, Affinity correspondence Diffusion DNA-Binding Proteins - metabolism Gene Deletion Glutathione Transferase - metabolism Histidine - chemistry Humans Infectious Diseases Kinetics Metabolic Diseases Molecular Medicine Neoplasm Proteins - metabolism Neurosciences Nitrogen Isotopes - metabolism Nuclear Magnetic Resonance, Biomolecular Protein Binding Protein Conformation Protein Folding Protein Structure, Tertiary Proto-Oncogene Proteins c-mdm2 - chemistry Proto-Oncogene Proteins c-mdm2 - metabolism Protons Recombinant Fusion Proteins - metabolism Spectrometry, Fluorescence Titrimetry Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - isolation & purification Tumor Suppressor Protein p53 - metabolism
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