Immunocytochemical distribution of NK-1 and NK-3 tachykinin receptors in isolated pancreatic acini of guinea pigs and rats

In this study, we investigated the immunocytochemical distribution of NK-1 and NK-3 tachykinin receptors in guinea pig and rat isolated pancreatic acini. In dispersed acinar cells from guinea pig, immunofluorescence staining detected similar densities of NK-1 and NK-3 receptors; conversely, rat acin...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2005-11, Vol.26 (11), p.2351-2354
Hauptverfasser:	Broccardo, Maria, Ciotti, M. Teresa, Linari, Giorgio, Agostini, Simona, Petrella, Carla, Amadoro, Giusy, Severini, Cinzia, Improta, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases - secretion Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Guinea pig Guinea Pigs Immunofluorescence Immunohistochemistry Male Pancreas, Exocrine - cytology Pancreas, Exocrine - metabolism Pancreas, Exocrine - secretion Pancreatic acini Rat Rats Rats, Wistar Receptors, Neurokinin-1 - biosynthesis Receptors, Neurokinin-3 - biosynthesis Species Specificity Tachykinin receptors Vertebrates: endocrinology
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Zusammenfassung:	In this study, we investigated the immunocytochemical distribution of NK-1 and NK-3 tachykinin receptors in guinea pig and rat isolated pancreatic acini. In dispersed acinar cells from guinea pig, immunofluorescence staining detected similar densities of NK-1 and NK-3 receptors; conversely, rat acinar cells expressed NK-1 receptors more strongly than NK-3 receptors. In line with previous functional studies, these immunocytochemical findings suggest that guinea pig NK-1 and NK-3 receptors and rat NK-1 receptors alone play a direct stimulatory role in the basal pancreatic acinar amylase release.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/j.peptides.2005.04.022