Umpolung Reactivity of Alkenyl Fischer Carbene Complexes, Copper Enolates, and Electrophiles

Umpolung Reactivity of Alkenyl Fischer Carbene Complexes, Copper Enolates, and Electrophiles

Copper makes the difference: An umpolung reactivity of Michael acceptors is observed when alkenyl carbene complexes react with copper ketone enolates and electrophiles. This reaction allows the straightforward synthesis of functionalized three‐component coupling products in a completely regio‐ and d...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-07, Vol.45 (29), p.4848-4850
Hauptverfasser: Barluenga, José, Mendoza, Abraham, Diéguez, Alejandro, Rodríguez, Félix, Fañanás, Francisco J.
Format: Artikel
Sprache:eng
Schlagworte:
carbenes
CC coupling
multicomponent reactions
synthetic methods
umpolung
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Beschreibung
Zusammenfassung:Copper makes the difference: An umpolung reactivity of Michael acceptors is observed when alkenyl carbene complexes react with copper ketone enolates and electrophiles. This reaction allows the straightforward synthesis of functionalized three‐component coupling products in a completely regio‐ and diastereoselective way.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200601364