Preparation of Substituted Pyrimido[4,5-b]-1,4-benzoxazepines, Thiazepines, and Diazepines via a Pictet−Spengler Cyclization
A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet−Spengler cyclization as a key step.
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| Veröffentlicht in: | Journal of organic chemistry 2005-11, Vol.70 (23), p.9629-9631 |
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| container_end_page | 9631 |
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| container_issue | 23 |
| container_start_page | 9629 |
| container_title | Journal of organic chemistry |
| container_volume | 70 |
| creator | Duncton, Matthew A. J Smith, Leon M Burdzovic-Wizeman, Sabina Burns, Aaron Liu, Hu Mao, Yunyu Wong, Wai C Kiselyov, Alexander S |
| description | A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet−Spengler cyclization as a key step. |
| doi_str_mv | 10.1021/jo051419g |
| format | Article |
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| ispartof | Journal of organic chemistry, 2005-11, Vol.70 (23), p.9629-9631 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Azepines - chemical synthesis Azepines - chemistry Catalysis Chemistry Cyclization Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Molecular Structure Organic chemistry Preparations and properties |
| title | Preparation of Substituted Pyrimido[4,5-b]-1,4-benzoxazepines, Thiazepines, and Diazepines via a Pictet−Spengler Cyclization |
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