Preparation of Substituted Pyrimido[4,5-b]-1,4-benzoxazepines, Thiazepines, and Diazepines via a Pictet−Spengler Cyclization

Preparation of Substituted Pyrimido[4,5-b]-1,4-benzoxazepines, Thiazepines, and Diazepines via a Pictet−Spengler Cyclization

A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet−Spengler cyclization as a key step.

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Veröffentlicht in:Journal of organic chemistry 2005-11, Vol.70 (23), p.9629-9631
Hauptverfasser: Duncton, Matthew A. J, Smith, Leon M, Burdzovic-Wizeman, Sabina, Burns, Aaron, Liu, Hu, Mao, Yunyu, Wong, Wai C, Kiselyov, Alexander S
Format: Artikel
Sprache:eng
Schlagworte:
Azepines - chemical synthesis
Azepines - chemistry
Catalysis
Chemistry
Cyclization
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Molecular Structure
Organic chemistry
Preparations and properties
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Beschreibung
Zusammenfassung:A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet−Spengler cyclization as a key step.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo051419g