Claudin proteins in human cancer : Promising new targets for diagnosis and therapy

The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the exact roles of these proteins in tumorigenesis...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-11, Vol.65 (21), p.9603-9606
1. Verfasser:	MORIN, Patrice J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Claudin-3 Claudin-4 General aspects Humans Medical sciences Membrane Proteins - biosynthesis Membrane Proteins - chemistry Membrane Proteins - metabolism Neoplasms - diagnosis Neoplasms - metabolism Neoplasms - therapy Pharmacology. Drug treatments Tight Junctions - metabolism Tumors
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Beschreibung
Zusammenfassung:	The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the exact roles of these proteins in tumorigenesis are still being uncovered, it is clear that they represent promising targets for cancer detection, diagnosis, and therapy.
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.can-05-2782