11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?

11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) catalyzes regeneration of active intracellular glucocorticoids in fat, liver, and discrete brain regions. Although overexpression of 11 beta-HSD1 in adipose tissue causes hyperphagia and the metabolic syndrome, male 11 beta-HSD1 null (11 bet...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2006-09, Vol.147 (9), p.4486-4495
Hauptverfasser:	Densmore, Valerie S, Morton, Nicholas M, Mullins, John J, Seckl, Jonathan R
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - biosynthesis 11-beta-Hydroxysteroid Dehydrogenase Type 1 - deficiency 11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics Agouti-Related Protein Animals Arcuate Nucleus of Hypothalamus - enzymology Corticosterone - blood Dietary Fats - administration & dosage Enkephalin, Ala-MePhe-Gly- - pharmacology Enzyme Induction Female Gene Expression Hyperphagia - enzymology Insulin - blood Intercellular Signaling Peptides and Proteins Leptin - blood Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - genetics Neurons - chemistry Neuropeptide Y - genetics Pro-Opiomelanocortin - genetics Proteins - genetics Receptor, Melanocortin, Type 4 - genetics Receptors, Opioid, mu - agonists RNA, Messenger - analysis Thyroid Hormones - blood Weight Gain
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