Enhanced bone ingrowth into hydroxyapatite with interconnected pores by Electrical Polarization

Hydroxyapatite (HA) ceramics are used as implants to repair damaged/removed bone, and negative or positive electrical polarization enhances osteoblast and decreases osteoclast activity, respectively, in vivo. We compared the ability of electrically polarized and non-polarized HA with interconnected...

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Veröffentlicht in:Biomaterials 2006-11, Vol.27 (32), p.5572-5579
Hauptverfasser: Itoh, Soichiro, Nakamura, Satoshi, Nakamura, Miho, Shinomiya, Kenichi, Yamashita, Kimihiro
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Sprache:eng
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Zusammenfassung:Hydroxyapatite (HA) ceramics are used as implants to repair damaged/removed bone, and negative or positive electrical polarization enhances osteoblast and decreases osteoclast activity, respectively, in vivo. We compared the ability of electrically polarized and non-polarized HA with interconnected pores (IPHA) implants to promote bone growth. Polarized or non-treated IPHAs were implanted into the right or left femoral condyle of rabbits ( N=10 in each group), and we performed histological examination, including enzymatic staining for osteoblasts and osteoclasts, 3 and 6 weeks after implantation. We observed improved bone ingrowth and increased osteoblast activity in polarized implants with complete bone penetration into polarized implants occurring as early as 3 weeks after surgery. In contrast, non-polarized implants were not fully ossified at 6 weeks after surgery. Furthermore, positively charged implant regions had decreased osteoclast activity compared to negatively charged or uncharged regions. We propose two different models to explain these observations.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2006.07.007