Light-induced fluorescence of the human cervix decreases after prostaglandin application for induction of labor at term
To define the changes in cervical light-induced fluorescence (LIF), an index of cross-linked collagen, after the use of locally applied prostaglandin preparations for labor induction at term and the correlation between LIF and Bishop-Score. The characteristic LIF of cervical collagen was measured fr...
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Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2005-11, Vol.123 (1), p.62-66 |
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Sprache: | eng |
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Zusammenfassung: | To define the changes in cervical light-induced fluorescence (LIF), an index of cross-linked collagen, after the use of locally applied prostaglandin preparations for labor induction at term and the correlation between LIF and Bishop-Score.
The characteristic LIF of cervical collagen was measured from the surface of the cervix using a specially designed instrument (collascope) in 41 gravidas undergoing labor induction at term by prostaglandins. LIF and Bishop-Score were obtained directly before and 4
h after the administration of prostaglandin. Paired Student's
t-test, Wilcoxon Signed Rank test, Linear Regression, Spearman correlation and Fisher Exact test were used as appropriate.
Cervical LIF decreased significantly after prostaglandin application (0.982
±
0.04 [before] to 0.885
±
0.037 [after],
p
=
0.025). The decrease in LIF correlated with the initial LIF before PG-application (
r
=
0.61). The Bishop-Score increased in all 41 patients. No correlation was found between LIF versus Bishop-Score.
Cervical application of prostaglandins decreases the amount of cross-linked collagen as measured by LIF. This effect was observed only in patients with a prior high cross-linked collagen. |
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ISSN: | 0301-2115 1872-7654 |
DOI: | 10.1016/j.ejogrb.2005.03.006 |