Halogenated Helianane Derivatives from the Sponge Spirastrella hartmani

Two new halogenated derivatives (1 and 2) of helianane (3) were isolated from the 2-propanol extract of the sponge Spirastrella hartmani. The structures of the new derivatives were determined on the basis of detailed spectroscopic analysis, including (+)-HREIMS and 1D and 2D NMR. Compound 1 showed i...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-10, Vol.68 (10), p.1554-1555
Hauptverfasser:	Martín, María Jesús, Berrué, Fabrice, Amade, Philippe, Fernández, Rogelio, Francesch, Andrés, Reyes, Fernando, Cuevas, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology Humans Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Spirastrella hartmani Tumor Cells, Cultured
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Zusammenfassung:	Two new halogenated derivatives (1 and 2) of helianane (3) were isolated from the 2-propanol extract of the sponge Spirastrella hartmani. The structures of the new derivatives were determined on the basis of detailed spectroscopic analysis, including (+)-HREIMS and 1D and 2D NMR. Compound 1 showed in vitro cytotoxicity against the human tumor cell lines A549, HT29, and MDA-MB-231.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np050247f