Bats Are Natural Reservoirs of SARS-Like Coronaviruses

Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbrea...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2005-10, Vol.310 (5748), p.676-679
Hauptverfasser:	Li, Wendong, Shi, Zhengli, Yu, Meng, Ren, Wuze, Smith, Craig, Epstein, Jonathan H, Wang, Hanzhong, Crameri, Gary, Hu, Zhihong, Zhang, Huajun, Zhang, Jianhong, McEachern, Jennifer, Field, Hume, Daszak, Peter, Eaton, Bryan T, Zhang, Shuyi, Wang, Lin-Fa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis Animals Bats Biological and medical sciences Biological variation Cercopithecus aethiops China - epidemiology Chiroptera Chiroptera - virology Coding Communicable Diseases, Emerging Coronavirus - classification Coronavirus infections Disease Outbreaks Disease Reservoirs Epidemics Epidemiology Fundamental and applied biological sciences. Psychology Genetic Variation Genome, Viral Genomes Henipavirus - classification Humans Medically important nuisances and vectors, pests of stored products and materials: population survey and control Microbiology Molecular Sequence Data Mutation Natural reservoirs Neurons Open reading frames Phylogeny Polymerase Chain Reaction SARS SARS coronavirus SARS virus SARS Virus - classification Sequence Analysis, DNA Severe acute respiratory syndrome Severe Acute Respiratory Syndrome - epidemiology Severe Acute Respiratory Syndrome - transmission Severe Acute Respiratory Syndrome - virology Vectors. Intermediate hosts Vero Cells Virology Viruses Viverridae - virology
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Beschreibung
Zusammenfassung:	Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1118391