Use of human VEGF(165) gene for therapeutic angiogenesis in coronary patients: first results

The paper presents the first results of therapeutic angiogenesis in clinical cardiosurgery: human VEGF(165) gene transplantation to coronary patients. The use of this therapeutic method is particularly effective in patients with inoperable cardiovascular injuries, i.e. patients with the most severe...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-07, Vol.140 (1), p.106-112
Hauptverfasser:	Bokeriya, L A, Golukhova, E Z, Eremeeva, M V, Aslanidi, I P, Merzlyakov, V Yu, Georgiev, G P, Kiselev, S L, Berishvili, I I, Vakhromeeva, M N, Serov, R A, Artyukhina, T V, Basarab, Yu S, Polyakova, E S, Lukashkin, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Coronary Disease - drug therapy Coronary Disease - surgery Coronary Vessels - drug effects Coronary Vessels - physiology Dose-Response Relationship, Drug Echocardiography Electrocardiography Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - therapeutic use Genetic Therapy - methods Humans Ischemia - drug therapy Middle Aged Muscle, Skeletal - blood supply Myocardial Revascularization Neovascularization, Physiologic - physiology Plasmids - genetics Plasmids - therapeutic use Positron-Emission Tomography Quality of Life Rats Tomography, Emission-Computed, Single-Photon Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - therapeutic use
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Zusammenfassung:	The paper presents the first results of therapeutic angiogenesis in clinical cardiosurgery: human VEGF(165) gene transplantation to coronary patients. The use of this therapeutic method is particularly effective in patients with inoperable cardiovascular injuries, i.e. patients with the most severe condition, in whom treatment remains little effective at the modern level of cardiosurgery development.
ISSN:	0007-4888
DOI:	10.1007/s10517-005-0424-x