Specificity by design
The specificity of a homing endonuclease has been altered using computational modeling of the protein-DNA interface.
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| Veröffentlicht in: | Nature biotechnology 2006-08, Vol.24 (8), p.954-955, Article 954 |
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| container_issue | 8 |
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| container_title | Nature biotechnology |
| container_volume | 24 |
| creator | Pabo, Carl O |
| description | The specificity of a homing endonuclease has been altered using computational modeling of the protein-DNA interface. |
| doi_str_mv | 10.1038/nbt0806-954 |
| format | Article |
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| identifier | ISSN: 1087-0156 |
| ispartof | Nature biotechnology, 2006-08, Vol.24 (8), p.954-955, Article 954 |
| issn | 1087-0156 1546-1696 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Agriculture Baker, David Base Pairing Base Sequence Binding Sites Bioinformatics Biomedical Engineering/Biotechnology Biomedicine Biotechnology Computational Biology - methods Computer Simulation Crystallography, X-Ray Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism Endonucleases - chemistry Endonucleases - genetics Endonucleases - metabolism Gene therapy Genomics Introns - genetics Life Sciences Models, Chemical Models, Molecular Monte Carlo Method news-and-views Protein Conformation Protein Engineering - methods Proteins Stoddard, Barry Substrate Specificity Thermodynamics |
| title | Specificity by design |
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