Specificity by design

The specificity of a homing endonuclease has been altered using computational modeling of the protein-DNA interface.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature biotechnology 2006-08, Vol.24 (8), p.954-955, Article 954
1. Verfasser:	Pabo, Carl O
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Baker, David Base Pairing Base Sequence Binding Sites Bioinformatics Biomedical Engineering/Biotechnology Biomedicine Biotechnology Computational Biology - methods Computer Simulation Crystallography, X-Ray Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism Endonucleases - chemistry Endonucleases - genetics Endonucleases - metabolism Gene therapy Genomics Introns - genetics Life Sciences Models, Chemical Models, Molecular Monte Carlo Method news-and-views Protein Conformation Protein Engineering - methods Proteins Stoddard, Barry Substrate Specificity Thermodynamics
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Beschreibung
Zusammenfassung:	The specificity of a homing endonuclease has been altered using computational modeling of the protein-DNA interface.
ISSN:	1087-0156 1546-1696
DOI:	10.1038/nbt0806-954