Electrostatic Basis for Enzyme Catalysis

The change in binding energy on moving from the reactant state to the transition state is the central issue of the origin of enzyme catalysis. Warshel et al analyze the finding of a major electrostatic contribution to catalysis and shown to reflect the preorganized polar environment of the enzyme ac...

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Veröffentlicht in:	Chemical reviews 2006-08, Vol.106 (8), p.3210-3235
Hauptverfasser:	Warshel, Arieh, Sharma, Pankaz K, Kato, Mitsunori, Xiang, Yun, Liu, Hanbin, Olsson, Mats H. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Binding Sites Biochemistry Biophysics Catalysis Electrocatalysis Enzymes Enzymes - chemistry Models, Chemical Phase transitions Quantum Theory Static Electricity Thermodynamics
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Beschreibung
Zusammenfassung:	The change in binding energy on moving from the reactant state to the transition state is the central issue of the origin of enzyme catalysis. Warshel et al analyze the finding of a major electrostatic contribution to catalysis and shown to reflect the preorganized polar environment of the enzyme active site.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr0503106