Mechanism underlying the effect of myelopeptides on lymphocyte proliferation in vitro

We studied the role of monocytes in the effect of myelopid and myelopeptides MP-1, MP-3, MP-5, and MP-6 on functional activity of peripheral blood lymphocytes in the reaction of blast transformation. Myelopeptides MP-1, MP-3, and MP-6 suppressed blast transformation of lymphocytes. The effect depend...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-07, Vol.140 (1), p.74-76
Hauptverfasser:	Gavrilova, T V, Gein, S V, Pogudina, T A, Chereshnev, V A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Dose-Response Relationship, Drug Humans Immunologic Factors - immunology Immunologic Factors - pharmacology Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Lymphocyte Activation - drug effects Male Oligopeptides - immunology Oligopeptides - pharmacology Scintillation Counting
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Zusammenfassung:	We studied the role of monocytes in the effect of myelopid and myelopeptides MP-1, MP-3, MP-5, and MP-6 on functional activity of peripheral blood lymphocytes in the reaction of blast transformation. Myelopeptides MP-1, MP-3, and MP-6 suppressed blast transformation of lymphocytes. The effect depended on the presence of monocytes in a cell culture.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0415-y