How does DNA sequence motif discovery work?

How can we computationally extract an unknown motif from a set of target sequences? What are the principles behind the major motif discovery algorithms? Which of these should we use, and how do we know we've found a 'real' motif?

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Bibliographische Detailangaben
Veröffentlicht in:	Nature biotechnology 2006-08, Vol.24 (8), p.959-961
1. Verfasser:	D'haeseleer, Patrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Algorithms Base Sequence Bioinformatics Biological and medical sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Conserved Sequence Deoxyribonucleic acid DNA DNA - analysis DNA - chemistry DNA - genetics DNA Footprinting - methods Fundamental and applied biological sciences. Psychology General aspects Genetics Life Sciences Mathematical analysis Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Molecular Sequence Data Pattern Recognition, Automated - methods primer Sequence Alignment - methods Sequence Analysis, DNA - methods Sequence Homology, Nucleic Acid
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Beschreibung
Zusammenfassung:	How can we computationally extract an unknown motif from a set of target sequences? What are the principles behind the major motif discovery algorithms? Which of these should we use, and how do we know we've found a 'real' motif?
ISSN:	1087-0156 1546-1696
DOI:	10.1038/nbt0806-959