Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios

Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios

Anorexia nervosa (AN) is a severe and complex psychiatric disorder with a significant genetic contribution. Previously, we found an association between AN and the 158Val/Met polymorphism of the catechol‐O‐methyltransferase (COMT) gene in a family‐based study of 51 Israeli AN trios. In the present st...

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Veröffentlicht in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2005-11, Vol.139B (1), p.45-50
Hauptverfasser: Michaelovsky, Elena, Frisch, Amos, Leor, Shani, Stein, Daniel, Danziger, Yardena, Carel, Cynthia, Fennig, Silvana, Mimouni, Marc, Klauck, Sabine M., Benner, Axel, Poustka, Annemarie, Apter, Alan, Weizman, Abraham
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Anorexia Nervosa - enzymology
Anorexia Nervosa - ethnology
Anorexia Nervosa - genetics
Anorexia Nervosa - physiopathology
Armadillo Domain Proteins - genetics
association
bingeing/purging
Catechol O-Methyltransferase - genetics
Cell Adhesion Molecules - genetics
Child
eating disorders
Female
Genetic Predisposition to Disease
Haplotypes
Humans
Israel
Jews - genetics
Linkage Disequilibrium
Male
Phosphoproteins - genetics
Polymorphism, Single Nucleotide
restricting
Risk Factors
transmission disequilibrium test (TDT)
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Zusammenfassung:Anorexia nervosa (AN) is a severe and complex psychiatric disorder with a significant genetic contribution. Previously, we found an association between AN and the 158Val/Met polymorphism of the catechol‐O‐methyltransferase (COMT) gene in a family‐based study of 51 Israeli AN trios. In the present study, we extended the original sample to include 85 family trios [66 AN restricting (AN‐R) and 19 bingeing/purging (AN‐BP) subtype] and performed a family‐based transmission disequilibrium test (TDT) analysis for five SNPs in the COMT and two in the adjacent ARVCF gene. Association was found between AN‐R and several SNPs in the COMT‐ARVCF region including the 158Val/Met polymorphism. TDT analysis of 5‐SNP haplotypes in AN‐R trios revealed an overall statistically significant transmission disequilibrium (P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30230