CD8 + T lymphocytes reactive against Epstein-Barr virus antigens in skin lesions of a patient with Sézary syndrome

Several studies have investigated the possible involvement of viral agents, and among them herpes viruses, in the development of cutaneous T-cell lymphoma. The aim of our study was to determine whether T cells specific to Epstein-Barr virus (EBV) antigens were detectable among tumor-infiltrating lym...

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Veröffentlicht in:Journal of the American Academy of Dermatology 2005-11, Vol.53 (5), p.897-900
Hauptverfasser: Knol, Anne-Chantal, Guilloux, Yannick, Quéreux, Gaëlle, Marques-Briand, Sonia, Pandolfino, Marie-Christine, Khammari, Amir, Dreno, Brigitte
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Sprache:eng
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Zusammenfassung:Several studies have investigated the possible involvement of viral agents, and among them herpes viruses, in the development of cutaneous T-cell lymphoma. The aim of our study was to determine whether T cells specific to Epstein-Barr virus (EBV) antigens were detectable among tumor-infiltrating lymphocytes infiltrating cutaneous lesions of a patient with Sézary syndrome. To analyze responses to EBV, we used a transient SV-40 origin-defective transformed simian cells transfection assay that permits an estimation of CD8 T-cell responses against a large number of HLA/viral protein combinations. This technique allowed the detection of EBV-specific T lymphocytes mainly directed against epitopes generated during the lytic cycle in the cutaneous lesions. This is, to our knowledge, the first description of the presence of EBV-specific T lymphocytes among tumor-infiltrating lymphocytes infiltrating the lesional skin of a patient with Sézary syndrome.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2005.07.044