Biosynthesis of TDP-D-Desosamine: Identification of a Strategy for C4 Deoxygenation

The proteins DesI and DesII are proposed to catalyze a C4 deoxygenation reaction to give the key intermediate 1 in the biosynthesis of D‐desosamine. Biochemical characterization of purified DesII showed that it is a member of the S‐adenosylmethionine (SAM) family of radical enzymes. The involvement...

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Veröffentlicht in:	Angewandte Chemie International Edition 2005-10, Vol.44 (41), p.6742-6746
Hauptverfasser:	Szu, Ping-hui, He, Xuemei, Zhao, Lishan, Liu, Hung-wen
Format:	Artikel
Sprache:	eng
Schlagworte:	amino sugars Amino Sugars - biosynthesis Amino Sugars - chemistry biosynthesis Catalysis deoxygenation desosamine Molecular Structure Nucleoside Diphosphate Sugars Oxygen - chemistry radicals Streptomyces - chemistry Streptomyces - metabolism Thymine Nucleotides - biosynthesis Thymine Nucleotides - chemistry
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Beschreibung
Zusammenfassung:	The proteins DesI and DesII are proposed to catalyze a C4 deoxygenation reaction to give the key intermediate 1 in the biosynthesis of D‐desosamine. Biochemical characterization of purified DesII showed that it is a member of the S‐adenosylmethionine (SAM) family of radical enzymes. The involvement of a SAM radical in the reaction with DesII identifies a new strategy for deoxygenation reactions of sugars.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200501998