Pilot Study of Trigeminal Nerve Stimulation (TNS) for Epilepsy: A Proof‐of‐Concept Trial

The safety and preliminary efficacy of trigeminal nerve stimulation (TNS) for epilepsy was evaluated in a pilot feasibility study of transcutaneous stimulation of the infraorbital and supraorbital branches of the trigeminal nerve. TNS was well tolerated. Four (57%) of seven subjects who completed ≥3...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2006-07, Vol.47 (7), p.1213-1215
Hauptverfasser:	DeGiorgio, Christopher M., Shewmon, Alan, Murray, Diane, Whitehurst, Todd
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Diseases of the nervous system Electric Stimulation Therapy - adverse effects Electric Stimulation Therapy - methods Epilepsy Epilepsy - drug therapy Epilepsy - prevention & control Epilepsy - therapy Face - innervation Feasibility Studies Functional Laterality - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Medical Records - statistics & numerical data Medical sciences Middle Aged Monitoring, Ambulatory Nervous system (semeiology, syndromes) Neurology Neuropharmacology Neurostimulation Pharmacology. Drug treatments Pilot Projects Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Treatment Outcome Trigeminal Nerve - physiology Trigeminal nerve stimulation
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Zusammenfassung:	The safety and preliminary efficacy of trigeminal nerve stimulation (TNS) for epilepsy was evaluated in a pilot feasibility study of transcutaneous stimulation of the infraorbital and supraorbital branches of the trigeminal nerve. TNS was well tolerated. Four (57%) of seven subjects who completed ≥3 months experienced a ≥50% reduction in seizure frequency. The results of this pilot study support further investigation into the safety and efficacy of TNS for epilepsy.
ISSN:	0013-9580 1528-1167
DOI:	10.1111/j.1528-1167.2006.00594.x