Enhanced Histone Acetylation and Transcription: A Dynamic Perspective

Enhanced Histone Acetylation and Transcription: A Dynamic Perspective

Stably enhanced histone acetylation has long been regarded as a condition of transcriptionally active genes. Recent papers suggest a more dynamic model, with rapid turnover of acetylation observed at nontranscribing “poised” genes and shown to be an important determinant of transcriptional efficienc...

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Veröffentlicht in:Molecular cell 2006-08, Vol.23 (3), p.289-296
Hauptverfasser: Clayton, Alison L., Hazzalin, Catherine A., Mahadevan, Louis C.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
Animals
Gene Expression Regulation
Histone Acetyltransferases - metabolism
Histone Deacetylases - metabolism
Histones - metabolism
Humans
Nucleosomes - genetics
Nucleosomes - metabolism
Transcription, Genetic - genetics
Transcriptional Activation
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Zusammenfassung:Stably enhanced histone acetylation has long been regarded as a condition of transcriptionally active genes. Recent papers suggest a more dynamic model, with rapid turnover of acetylation observed at nontranscribing “poised” genes and shown to be an important determinant of transcriptional efficiency upon gene induction. Are these “special cases,” restricted to specific genes and specific types of histone modifications, or could the entire panoply of histone modifications associated with transcription now be revisited with a much more dynamic perspective?
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2006.06.017