Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases
The biocatalytic reduction of α-alkyl-1,3-diketones and α-alkyl-β-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.
Gespeichert in:
| Veröffentlicht in: | Organic letters 2005-10, Vol.7 (22), p.4799-4801 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4801 |
|---|---|
| container_issue | 22 |
| container_start_page | 4799 |
| container_title | Organic letters |
| container_volume | 7 |
| creator | Kalaitzakis, Dimitris Rozzell, J. David Kambourakis, Spiros Smonou, Ioulia |
| description | The biocatalytic reduction of α-alkyl-1,3-diketones and α-alkyl-β-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters. |
| doi_str_mv | 10.1021/ol051166d |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68707584</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68707584</sourcerecordid><originalsourceid>FETCH-LOGICAL-a313t-18a133800a28eefca3dad0c5d710231b92993b10affa85baa721750da1cc69b53</originalsourceid><addsrcrecordid>eNptkM9OFEEQxjtEIwgcfAHTF01MaOyatufPcbOgSyBIFM6TmukaHeidXqZmTMZn8GXgQXgmG3cDF0_1pepXX6U-Id6APgSdwMfgtQVIU7cldsAmRmXaJi-edKq3xWvma60hdopXYhvSxNi8SHbEn0X746ef5PeBegpMnuqh_UXyG7kxqtCxDI18uFMzfzN5BQdGufaGhtARS-zc8-jhXj325TFHK5ZzHNBPv8nJapInHDwOUZ_Pji4W6ohW1DnqBnkaN_p_p5CJ98TLBj3T_qbuiqvPx5fzhTr7-uVkPjtTaMAMCnIEY3KtMcmJmhqNQ6dr67KYhoGqSIrCVKCxaTC3FWKWQGa1Q6jrtKis2RXv176rPtyOxEO5bLkm77GjMHKZ5pnObP4pgh_WYN0H5p6actW3S-ynEnT5GH35FH1k325Mx2pJ7pncZB2Bd2sAay6vw9h38cf_GP0FsVuN4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68707584</pqid></control><display><type>article</type><title>Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases</title><source>ACS Publications</source><source>MEDLINE</source><creator>Kalaitzakis, Dimitris ; Rozzell, J. David ; Kambourakis, Spiros ; Smonou, Ioulia</creator><creatorcontrib>Kalaitzakis, Dimitris ; Rozzell, J. David ; Kambourakis, Spiros ; Smonou, Ioulia</creatorcontrib><description>The biocatalytic reduction of α-alkyl-1,3-diketones and α-alkyl-β-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.</description><identifier>ISSN: 1523-7060</identifier><identifier>EISSN: 1523-7052</identifier><identifier>DOI: 10.1021/ol051166d</identifier><identifier>PMID: 16235892</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Catalysis ; Esters - chemistry ; Esters - metabolism ; Ketones - chemistry ; Ketones - metabolism ; Molecular Structure ; NADP - chemistry ; Oxidation-Reduction ; Oxidoreductases - chemistry ; Stereoisomerism</subject><ispartof>Organic letters, 2005-10, Vol.7 (22), p.4799-4801</ispartof><rights>Copyright © 2005 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a313t-18a133800a28eefca3dad0c5d710231b92993b10affa85baa721750da1cc69b53</citedby><cites>FETCH-LOGICAL-a313t-18a133800a28eefca3dad0c5d710231b92993b10affa85baa721750da1cc69b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ol051166d$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ol051166d$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16235892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalaitzakis, Dimitris</creatorcontrib><creatorcontrib>Rozzell, J. David</creatorcontrib><creatorcontrib>Kambourakis, Spiros</creatorcontrib><creatorcontrib>Smonou, Ioulia</creatorcontrib><title>Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases</title><title>Organic letters</title><addtitle>Org. Lett</addtitle><description>The biocatalytic reduction of α-alkyl-1,3-diketones and α-alkyl-β-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.</description><subject>Catalysis</subject><subject>Esters - chemistry</subject><subject>Esters - metabolism</subject><subject>Ketones - chemistry</subject><subject>Ketones - metabolism</subject><subject>Molecular Structure</subject><subject>NADP - chemistry</subject><subject>Oxidation-Reduction</subject><subject>Oxidoreductases - chemistry</subject><subject>Stereoisomerism</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9OFEEQxjtEIwgcfAHTF01MaOyatufPcbOgSyBIFM6TmukaHeidXqZmTMZn8GXgQXgmG3cDF0_1pepXX6U-Id6APgSdwMfgtQVIU7cldsAmRmXaJi-edKq3xWvma60hdopXYhvSxNi8SHbEn0X746ef5PeBegpMnuqh_UXyG7kxqtCxDI18uFMzfzN5BQdGufaGhtARS-zc8-jhXj325TFHK5ZzHNBPv8nJapInHDwOUZ_Pji4W6ohW1DnqBnkaN_p_p5CJ98TLBj3T_qbuiqvPx5fzhTr7-uVkPjtTaMAMCnIEY3KtMcmJmhqNQ6dr67KYhoGqSIrCVKCxaTC3FWKWQGa1Q6jrtKis2RXv176rPtyOxEO5bLkm77GjMHKZ5pnObP4pgh_WYN0H5p6actW3S-ynEnT5GH35FH1k325Mx2pJ7pncZB2Bd2sAay6vw9h38cf_GP0FsVuN4g</recordid><startdate>20051027</startdate><enddate>20051027</enddate><creator>Kalaitzakis, Dimitris</creator><creator>Rozzell, J. David</creator><creator>Kambourakis, Spiros</creator><creator>Smonou, Ioulia</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051027</creationdate><title>Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases</title><author>Kalaitzakis, Dimitris ; Rozzell, J. David ; Kambourakis, Spiros ; Smonou, Ioulia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a313t-18a133800a28eefca3dad0c5d710231b92993b10affa85baa721750da1cc69b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Catalysis</topic><topic>Esters - chemistry</topic><topic>Esters - metabolism</topic><topic>Ketones - chemistry</topic><topic>Ketones - metabolism</topic><topic>Molecular Structure</topic><topic>NADP - chemistry</topic><topic>Oxidation-Reduction</topic><topic>Oxidoreductases - chemistry</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalaitzakis, Dimitris</creatorcontrib><creatorcontrib>Rozzell, J. David</creatorcontrib><creatorcontrib>Kambourakis, Spiros</creatorcontrib><creatorcontrib>Smonou, Ioulia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Organic letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalaitzakis, Dimitris</au><au>Rozzell, J. David</au><au>Kambourakis, Spiros</au><au>Smonou, Ioulia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases</atitle><jtitle>Organic letters</jtitle><addtitle>Org. Lett</addtitle><date>2005-10-27</date><risdate>2005</risdate><volume>7</volume><issue>22</issue><spage>4799</spage><epage>4801</epage><pages>4799-4801</pages><issn>1523-7060</issn><eissn>1523-7052</eissn><abstract>The biocatalytic reduction of α-alkyl-1,3-diketones and α-alkyl-β-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>16235892</pmid><doi>10.1021/ol051166d</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2005-10, Vol.7 (22), p.4799-4801 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68707584 |
| source | ACS Publications; MEDLINE |
| subjects | Catalysis Esters - chemistry Esters - metabolism Ketones - chemistry Ketones - metabolism Molecular Structure NADP - chemistry Oxidation-Reduction Oxidoreductases - chemistry Stereoisomerism |
| title | Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T21%3A48%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Highly%20Stereoselective%20Reductions%20of%20%CE%B1-Alkyl-1,3-diketones%20and%20%CE%B1-Alkyl-%CE%B2-keto%20Esters%20Catalyzed%20by%20Isolated%20NADPH-Dependent%20Ketoreductases&rft.jtitle=Organic%20letters&rft.au=Kalaitzakis,%20Dimitris&rft.date=2005-10-27&rft.volume=7&rft.issue=22&rft.spage=4799&rft.epage=4801&rft.pages=4799-4801&rft.issn=1523-7060&rft.eissn=1523-7052&rft_id=info:doi/10.1021/ol051166d&rft_dat=%3Cproquest_cross%3E68707584%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68707584&rft_id=info:pmid/16235892&rfr_iscdi=true |