Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases

Highly Stereoselective Reductions of α-Alkyl-1,3-diketones and α-Alkyl-β-keto Esters Catalyzed by Isolated NADPH-Dependent Ketoreductases

The biocatalytic reduction of α-alkyl-1,3-diketones and α-alkyl-β-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.

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Veröffentlicht in:Organic letters 2005-10, Vol.7 (22), p.4799-4801
Hauptverfasser: Kalaitzakis, Dimitris, Rozzell, J. David, Kambourakis, Spiros, Smonou, Ioulia
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Esters - chemistry
Esters - metabolism
Ketones - chemistry
Ketones - metabolism
Molecular Structure
NADP - chemistry
Oxidation-Reduction
Oxidoreductases - chemistry
Stereoisomerism
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Zusammenfassung:The biocatalytic reduction of α-alkyl-1,3-diketones and α-alkyl-β-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol051166d