Fluostatins C∼E, Novel Members of the Fluostatin Family Produced by Streptomyces Strain Acta 1383

Three new members of the fluostatin family, fluostatins C∼E, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S...

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Veröffentlicht in:	Journal of antibiotics 2006-05, Vol.59 (5), p.293-297
Hauptverfasser:	Baur, Stefanie, Niehaus, Jörg, Karagouni, Amalia D, Katsifas, Efstathios A, Chalkou, Kalliopi, Meintanis, Christos, Jones, Amanda L, Goodfellow, Michael, Ward, Alan C, Beil, Winfried, Schneider, Kathrin, Süssmuth, Roderich D, Fiedler, Hans-Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Filtrate Fluorenes - chemistry Fluorenes - isolation & purification Fluorenes - pharmacology Humans Life Sciences Liquid chromatography Medicinal Chemistry Microbiology Molecular Structure Organic Chemistry original-article Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Ultraviolet Streptomyces Streptomyces - chemistry Streptomyces lavendulae
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Beschreibung
Zusammenfassung:	Three new members of the fluostatin family, fluostatins C∼E, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2006.41