Structural Characterization of Ultrasmall Superparamagnetic Iron Oxide (USPIO) Particles in Aqueous Suspension by Energy Dispersive X-ray Diffraction (EDXD)

Ultrasmall superparamagnetic iron oxide (USPIO) particles were structurally characterized in situ in an aqueous dilute suspension by energy dispersive X-ray diffraction (EDXD) and ex situ as powders obtained by lyophilization of the suspension by angular dispersive X-ray diffraction (ADXD) at 20 °C....

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Veröffentlicht in:Journal of the American Chemical Society 2006-08, Vol.128 (31), p.10054-10059
Hauptverfasser: Di Marco, Mariagrazia, Port, Marc, Couvreur, Patrick, Dubernet, Catherine, Ballirano, Paolo, Sadun, Claudia
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Sprache:eng
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Zusammenfassung:Ultrasmall superparamagnetic iron oxide (USPIO) particles were structurally characterized in situ in an aqueous dilute suspension by energy dispersive X-ray diffraction (EDXD) and ex situ as powders obtained by lyophilization of the suspension by angular dispersive X-ray diffraction (ADXD) at 20 °C. Structural parameters obtained by the Rietveld method on ADXD data were used as starting parameters for modeling the structure of the particles in suspension. Although each particle is a single crystal, as evidenced by conventional X-ray diffraction, our results indicate that the structural order, specific to a crystal, does not extend to the entire volume of the particle. In fact, each individual particle, averagely, has a crystalline structural extension ca. 4.0 nm smaller than the apparent dimensions obtained by both ADXD and TEM (ca. 8.0 nm).
ISSN:0002-7863
1520-5126
DOI:10.1021/ja061674y