Radiosensitivity enhancement by celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2-dependent cell cycle regulation on human cancer cells expressing differential COX-2 levels

To characterize the radiation-enhancing effects on human cancer cells and underlying mechanisms of celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, and to ascertain whether its effects are COX-2 dependent. Clonogenic cytotoxicity assays and radiation survival assays after treatment with cele...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-10, Vol.65 (20), p.9501-9509
Hauptverfasser:	YOU KEUN SHIN, JI SUN PARK, HYUN SEOK KIM, HYUN JUNG JUN, GWI EON KIM, CHANG OK SUH, YEON SOOK YUN, PYO, Hongryull
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Apoptosis - radiation effects Biological and medical sciences Celecoxib Cell Cycle - physiology Cell Cycle - radiation effects Cell Line, Tumor Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cyclooxygenase 2 - biosynthesis Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Dinoprostone - pharmacology HCT116 Cells Humans Medical sciences Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - radiotherapy Pharmacology. Drug treatments Pyrazoles - pharmacology Radiation Tolerance - drug effects Radiation-Sensitizing Agents - pharmacology Sulfonamides - pharmacology Tumors
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