Constituents of Chrysothamnus viscidiflorus

The aerial parts of Chrysothamnus viscidiflorus var. viscidiflorus afforded three new and seven known compounds. Structures of compounds were determined by spectroscopic methods. Four compounds showed anti-cancer activity against human breast cancer cells. A phytochemical investigation of the aerial parts of Chrysothamnus viscidiflorus var. viscidiflorus afforded three new [chrysothol ( 1), 2 and 4] and seven known compounds, including five sesquiterpenes, two cinnamic acid derivatives, two ketoalcohol derivatives and one coumarin glucoside. The structures of two previously reported compounds, 1b and 1c, were revised on the basis of chemical reaction. Structures of the compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and X-ray analysis. The unpublished X-ray data of the known compounds 6 and 7 are reported. Compounds chrysothol ( 1), and 8– 10 showed anti-cancer activity against human breast cancer cells.