Correction of massive hydrocephalus and brain wound in holoprosencephaly

Holoprosencephaly is a rare disorder of embryologic development that denotes an incomplete or absent division of the embryonic forebrain (prosencephalon) into distinct lateral cerebral hemispheres. In most cases of holoprosencephaly, the fetus fails to survive to term, and those that do survive have...

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Veröffentlicht in:The Journal of craniofacial surgery 2006-07, Vol.17 (4), p.707-713
Hauptverfasser: Dickinson, Brian P, Spoon, Daniel B, Cordray, Tracy L, Lazareff, Jorge, Wasson, Kristy, Bradley, James P
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Sprache:eng
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Zusammenfassung:Holoprosencephaly is a rare disorder of embryologic development that denotes an incomplete or absent division of the embryonic forebrain (prosencephalon) into distinct lateral cerebral hemispheres. In most cases of holoprosencephaly, the fetus fails to survive to term, and those that do survive have severe functional limitations, including mental retardation. We present a case report of cranial vault remodeling in a 20-month-old female who was born with holoprosencephaly and a severe number 0/14 cleft. The patient developed chronic nonhealing ulcers secondary to hydrocephalus, ventriculoperitoneal shunts, and the underlying architecture of her cranial vault.
ISSN:1049-2275
DOI:10.1097/00001665-200607000-00019