Cellular adoptive immunotherapy after allogeneic stem cell transplantation

PURPOSE OF REVIEWThis review presents the role of donor lymphocyte infusion, natural killer cells, and dendritic cells in cellular immunotherapy after allogeneic stem cell transplantation. RECENT FINDINGSIt becomes increasingly possible to infuse more specialized subsets of lymphocyte cells after transplantation. The infusion of natural killer cells, especially in non human leukocyte antigen-identical transplantation, may become an important tool in enhancing the graft-versus-tumor effect. Vaccination of patients after stem cell transplantation with autologous-derived dendritic cells merits further investigation. SUMMARYStem cell transplantation has evolved to a specialized form of immunotherapy.