Serum aluminium and cobalt levels after ceramic-on-ceramic and metal-on-metal total hip replacement
In a randomised study, 28 patients with a mean age of 62.2 years (32 to 81) with osteoarthritis or avascular necrosis of the hip received either a ceramic-on-ceramic or a metal-on-metal total hip replacement. Apart from the liners the acetabular and femoral components were made of Ti-Al-Nb alloy. Th...
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| Veröffentlicht in: | Journal of bone and joint surgery. British volume 2006-08, Vol.88 (8), p.1003-1005 |
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| container_title | Journal of bone and joint surgery. British volume |
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| creator | GRÜBL, A WEISSINGER, M BRODNER, W GLEISS, A GIUREA, A GRUBER, M POLL, G MEISINGER, V GOTTSAUNER-WOLF, F KOTZ, R |
| description | In a randomised study, 28 patients with a mean age of 62.2 years (32 to 81) with osteoarthritis or avascular necrosis of the hip received either a ceramic-on-ceramic or a metal-on-metal total hip replacement. Apart from the liners the acetabular and femoral components were made of Ti-Al-Nb alloy. The serum aluminium and cobalt levels were measured before, and at one year after surgery. The 15 patients in the ceramic-on-ceramic group had a median pre-operative aluminium level of 1.3 microg/l (0.25 to 8.4) and a cobalt level below the detection limit. At one year the aluminium level was 1.1 microg/l (0.25 to 2.3) and the cobalt level was 0.4 microg/l (0.15 to 0.7). The 13 patients in the metal-on-metal group had a median pre-operative aluminium level of 1.9 microg/l (0.25 to 4.4) and a cobalt level below the detection limit. At one year the median aluminium level was 0.9 microg/l (0.25 to 3.9) whereas the cobalt level was 1.4 microg/l (0.5 to 10.5). This increase in the cobalt level at one year was significant (p < 0.001). Our findings indicate that ceramic-on-ceramic bearings do not cause elevated levels of serum aluminium in the first post-operative year. |
| doi_str_mv | 10.1302/0301-620X.88B8.17870 |
| format | Article |
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Apart from the liners the acetabular and femoral components were made of Ti-Al-Nb alloy. The serum aluminium and cobalt levels were measured before, and at one year after surgery. The 15 patients in the ceramic-on-ceramic group had a median pre-operative aluminium level of 1.3 microg/l (0.25 to 8.4) and a cobalt level below the detection limit. At one year the aluminium level was 1.1 microg/l (0.25 to 2.3) and the cobalt level was 0.4 microg/l (0.15 to 0.7). The 13 patients in the metal-on-metal group had a median pre-operative aluminium level of 1.9 microg/l (0.25 to 4.4) and a cobalt level below the detection limit. At one year the median aluminium level was 0.9 microg/l (0.25 to 3.9) whereas the cobalt level was 1.4 microg/l (0.5 to 10.5). This increase in the cobalt level at one year was significant (p < 0.001). Our findings indicate that ceramic-on-ceramic bearings do not cause elevated levels of serum aluminium in the first post-operative year.</description><edition>British volume</edition><identifier>ISSN: 0301-620X</identifier><identifier>ISSN: 2049-4394</identifier><identifier>EISSN: 2044-5377</identifier><identifier>EISSN: 2049-4408</identifier><identifier>DOI: 10.1302/0301-620X.88B8.17870</identifier><identifier>PMID: 16877596</identifier><identifier>CODEN: JBSUAK</identifier><language>eng</language><publisher>London: British Editorial Society of Bone and Joint Surgery</publisher><subject>Acetabulum - surgery ; Adult ; Aged ; Aged, 80 and over ; Aluminum - blood ; Arthroplasty, Replacement, Hip - instrumentation ; Arthroplasty, Replacement, Hip - methods ; Biological and medical sciences ; Ceramics ; Cobalt - blood ; Diseases of the osteoarticular system ; Female ; Femur - surgery ; Femur Head Necrosis - blood ; Femur Head Necrosis - surgery ; Humans ; Male ; Medical sciences ; Metals ; Middle Aged ; Orthopedic surgery ; Osteoarthritis - blood ; Osteoarthritis - surgery ; Prospective Studies ; Prosthesis Design ; Surgery (general aspects). 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British volume</title><addtitle>J Bone Joint Surg Br</addtitle><description>In a randomised study, 28 patients with a mean age of 62.2 years (32 to 81) with osteoarthritis or avascular necrosis of the hip received either a ceramic-on-ceramic or a metal-on-metal total hip replacement. Apart from the liners the acetabular and femoral components were made of Ti-Al-Nb alloy. The serum aluminium and cobalt levels were measured before, and at one year after surgery. The 15 patients in the ceramic-on-ceramic group had a median pre-operative aluminium level of 1.3 microg/l (0.25 to 8.4) and a cobalt level below the detection limit. At one year the aluminium level was 1.1 microg/l (0.25 to 2.3) and the cobalt level was 0.4 microg/l (0.15 to 0.7). The 13 patients in the metal-on-metal group had a median pre-operative aluminium level of 1.9 microg/l (0.25 to 4.4) and a cobalt level below the detection limit. At one year the median aluminium level was 0.9 microg/l (0.25 to 3.9) whereas the cobalt level was 1.4 microg/l (0.5 to 10.5). This increase in the cobalt level at one year was significant (p < 0.001). Our findings indicate that ceramic-on-ceramic bearings do not cause elevated levels of serum aluminium in the first post-operative year.</description><subject>Acetabulum - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aluminum - blood</subject><subject>Arthroplasty, Replacement, Hip - instrumentation</subject><subject>Arthroplasty, Replacement, Hip - methods</subject><subject>Biological and medical sciences</subject><subject>Ceramics</subject><subject>Cobalt - blood</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Femur - surgery</subject><subject>Femur Head Necrosis - blood</subject><subject>Femur Head Necrosis - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals</subject><subject>Middle Aged</subject><subject>Orthopedic surgery</subject><subject>Osteoarthritis - blood</subject><subject>Osteoarthritis - surgery</subject><subject>Prospective Studies</subject><subject>Prosthesis Design</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Treatment Outcome</subject><issn>0301-620X</issn><issn>2049-4394</issn><issn>2044-5377</issn><issn>2049-4408</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxTAURYMoen38gUgRdNbryaN5DFV8geBABWchTROspO01aQX_3vZaFJw4STaHtQ8cFkKHGJaYAjkDCjjnBF6WUl7IJRZSwAZaEGAsL6gQm2jxg-yg3ZTeAIAVBd1GO5hLIQrFF8g-ujg0mQlDU7f1lNoqs11pQp8F9-FCyozvXcysi6apbd61-RzXaON6E6bhOmR9N72v9SqLbhWMdY1r-3205U1I7mD-99Dz9dXT5W1-_3Bzd3l-n1taMMi98qXgVoKQUFqhCK4EZ0RyI1WlKmo8cO8ZiJJ5TwtFPYxFz8g4drjkdA-dfu9dxe59cKnXTZ2sC8G0rhuS5nI8m2L1L4hVgSXICTz-A751Q2zHIzQhiismJR4h9g3Z2KUUnderWDcmfmoMelKlJw968qAnVXqtaqwdzbuHsnHVb2l2MwInM2CSNcFH09o6_XISCCiq6Bc7dJt1</recordid><startdate>200608</startdate><enddate>200608</enddate><creator>GRÜBL, A</creator><creator>WEISSINGER, M</creator><creator>BRODNER, W</creator><creator>GLEISS, A</creator><creator>GIUREA, A</creator><creator>GRUBER, M</creator><creator>POLL, G</creator><creator>MEISINGER, V</creator><creator>GOTTSAUNER-WOLF, F</creator><creator>KOTZ, R</creator><general>British Editorial Society of Bone and Joint Surgery</general><general>British Editorial Society of Bone & Joint Surgery</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QP</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200608</creationdate><title>Serum aluminium and cobalt levels after ceramic-on-ceramic and metal-on-metal total hip replacement</title><author>GRÜBL, A ; WEISSINGER, M ; BRODNER, W ; GLEISS, A ; GIUREA, A ; GRUBER, M ; POLL, G ; MEISINGER, V ; GOTTSAUNER-WOLF, F ; KOTZ, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3540-f9fb76c80780bc7921d764286a89d9d3af06ff407b4ff3593f0c35f4206fe1b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acetabulum - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aluminum - blood</topic><topic>Arthroplasty, Replacement, Hip - instrumentation</topic><topic>Arthroplasty, Replacement, Hip - methods</topic><topic>Biological and medical sciences</topic><topic>Ceramics</topic><topic>Cobalt - blood</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Femur - surgery</topic><topic>Femur Head Necrosis - blood</topic><topic>Femur Head Necrosis - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals</topic><topic>Middle Aged</topic><topic>Orthopedic surgery</topic><topic>Osteoarthritis - blood</topic><topic>Osteoarthritis - surgery</topic><topic>Prospective Studies</topic><topic>Prosthesis Design</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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British volume</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GRÜBL, A</au><au>WEISSINGER, M</au><au>BRODNER, W</au><au>GLEISS, A</au><au>GIUREA, A</au><au>GRUBER, M</au><au>POLL, G</au><au>MEISINGER, V</au><au>GOTTSAUNER-WOLF, F</au><au>KOTZ, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum aluminium and cobalt levels after ceramic-on-ceramic and metal-on-metal total hip replacement</atitle><jtitle>Journal of bone and joint surgery. British volume</jtitle><addtitle>J Bone Joint Surg Br</addtitle><date>2006-08</date><risdate>2006</risdate><volume>88</volume><issue>8</issue><spage>1003</spage><epage>1005</epage><pages>1003-1005</pages><issn>0301-620X</issn><issn>2049-4394</issn><eissn>2044-5377</eissn><eissn>2049-4408</eissn><coden>JBSUAK</coden><abstract>In a randomised study, 28 patients with a mean age of 62.2 years (32 to 81) with osteoarthritis or avascular necrosis of the hip received either a ceramic-on-ceramic or a metal-on-metal total hip replacement. Apart from the liners the acetabular and femoral components were made of Ti-Al-Nb alloy. The serum aluminium and cobalt levels were measured before, and at one year after surgery. The 15 patients in the ceramic-on-ceramic group had a median pre-operative aluminium level of 1.3 microg/l (0.25 to 8.4) and a cobalt level below the detection limit. At one year the aluminium level was 1.1 microg/l (0.25 to 2.3) and the cobalt level was 0.4 microg/l (0.15 to 0.7). The 13 patients in the metal-on-metal group had a median pre-operative aluminium level of 1.9 microg/l (0.25 to 4.4) and a cobalt level below the detection limit. At one year the median aluminium level was 0.9 microg/l (0.25 to 3.9) whereas the cobalt level was 1.4 microg/l (0.5 to 10.5). This increase in the cobalt level at one year was significant (p < 0.001). Our findings indicate that ceramic-on-ceramic bearings do not cause elevated levels of serum aluminium in the first post-operative year.</abstract><cop>London</cop><pub>British Editorial Society of Bone and Joint Surgery</pub><pmid>16877596</pmid><doi>10.1302/0301-620X.88B8.17870</doi><tpages>3</tpages><edition>British volume</edition><oa>free_for_read</oa></addata></record> |
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| subjects | Acetabulum - surgery Adult Aged Aged, 80 and over Aluminum - blood Arthroplasty, Replacement, Hip - instrumentation Arthroplasty, Replacement, Hip - methods Biological and medical sciences Ceramics Cobalt - blood Diseases of the osteoarticular system Female Femur - surgery Femur Head Necrosis - blood Femur Head Necrosis - surgery Humans Male Medical sciences Metals Middle Aged Orthopedic surgery Osteoarthritis - blood Osteoarthritis - surgery Prospective Studies Prosthesis Design Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Treatment Outcome |
| title | Serum aluminium and cobalt levels after ceramic-on-ceramic and metal-on-metal total hip replacement |
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