A formal synthesis of (+)-lactacystin

A formal synthesis of (+)-lactacystin

A synthetic route to the neurotrophic agent (+)-lactacystin has been developed utilizing a base-promoted intramolecular alkylidenecarbene C-H insertion as the key transformation.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2005-10 (40), p.5106-5108
Hauptverfasser: Wardrop, Duncan J, Bowen, Edward G
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcysteine - analogs & derivatives
Acetylcysteine - chemical synthesis
Acetylcysteine - chemistry
Alkylation
Hydrocarbons - chemistry
Methane - analogs & derivatives
Methane - chemistry
Molecular Structure
Pyrroles - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A synthetic route to the neurotrophic agent (+)-lactacystin has been developed utilizing a base-promoted intramolecular alkylidenecarbene C-H insertion as the key transformation.
ISSN:1359-7345
1364-548X
DOI:10.1039/b508300a