β-cyclodextrin-immobilized (4S)-phenoxy-(S)-proline as a catalyst for direct asymmetric aldol reactions

β-cyclodextrin-immobilized (4S)-phenoxy-(S)-proline as a catalyst for direct asymmetric aldol reactions

β‐Cyclodextrin‐immobilized (4S)‐phenoxy‐(S)‐proline was prepared conveniently by simply heating the amino acid and β‐cyclodextrin in ethanol–water (1/1, v/v) and removal of the solvent. This proved to be an efficient catalyst for direct asymmetric aldol reactions, and the catalyst could be recycled...

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Veröffentlicht in:Chirality (New York, N.Y.) N.Y.), 2005, Vol.17 (9), p.556-558
Hauptverfasser: Shen, Zongxuan, Ma, Jimei, Liu, Yanhua, Jiao, Chongjun, Li, Ming, Zhang, Yawen
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - chemistry
asymmetric aldol reaction
beta-Cyclodextrins - chemistry
Catalysis
immobilized catalyst
Magnetic Resonance Spectroscopy
Molecular Structure
Proline - analogs & derivatives
Proline - chemistry
Solvents - chemistry
Spectrum Analysis
Stereoisomerism
β-cyclodextrin
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Zusammenfassung:β‐Cyclodextrin‐immobilized (4S)‐phenoxy‐(S)‐proline was prepared conveniently by simply heating the amino acid and β‐cyclodextrin in ethanol–water (1/1, v/v) and removal of the solvent. This proved to be an efficient catalyst for direct asymmetric aldol reactions, and the catalyst could be recycled four times without loss of enantioselectivity. © 2005 Wiley‐Liss, Inc. Chirality 17:556–558, 2005.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.20208