Organogenesis of the endocrine pancreas

Organogenesis of the endocrine pancreas. Embryonic pancreatic primordia transplanted into diabetic animal hosts undergo selective endocrine differentiation in situ and normalize glucose tolerance. Pancreatic primordia can be transplanted across isogeneic, allogeneic, and both concordant (rat to mous...

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Veröffentlicht in:	Kidney international 2005-11, Vol.68 (5), p.1953-1955
1. Verfasser:	Hammerman, Marc R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diabetes Mellitus, Type 1 - surgery Fetal Tissue Transplantation Humans Islets of Langerhans - embryology Medical sciences Nephrology. Urinary tract diseases Pancreas Transplantation Transplantation, Heterologous
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Beschreibung
Zusammenfassung:	Organogenesis of the endocrine pancreas. Embryonic pancreatic primordia transplanted into diabetic animal hosts undergo selective endocrine differentiation in situ and normalize glucose tolerance. Pancreatic primordia can be transplanted across isogeneic, allogeneic, and both concordant (rat to mouse) and highly disparate (pig to rodent) xenogeneic barriers. This review explores the therapeutic potential for pancreatic organogenesis posttransplantation of embryonic primordia.
ISSN:	0085-2538 1523-1755
DOI:	10.1111/j.1523-1755.2005.00628.x