Alternative Splicing— When Two’s a Crowd

Various mechanisms have been proposed to explain mutually exclusive splicing of pairs of exons. A paper in this issue of Cell ( Graveley, 2005) provides a fascinating insight into the perplexing question of how only one exon at a time is chosen from an array of 48 exons in the Drosophila Dscam gene.

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Bibliographische Detailangaben
Veröffentlicht in:	Cell 2005-10, Vol.123 (1), p.1-3
1. Verfasser:	Smith, Christopher W.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Animals Cell Adhesion Molecules Drosophila Drosophila melanogaster - genetics Drosophila Proteins - biosynthesis Drosophila Proteins - genetics Exons - genetics Gene Expression Regulation - genetics Humans RNA Splice Sites - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Spliceosomes - genetics
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Beschreibung
Zusammenfassung:	Various mechanisms have been proposed to explain mutually exclusive splicing of pairs of exons. A paper in this issue of Cell ( Graveley, 2005) provides a fascinating insight into the perplexing question of how only one exon at a time is chosen from an array of 48 exons in the Drosophila Dscam gene.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2005.09.010